Swim stress differentially blocks CRF receptor mediated responses in dorsal raphe nucleus
نویسندگان
چکیده
منابع مشابه
Effects of aging on stress-related responses of serotonergic neurons in the dorsal raphe nucleus of male rats
Responses to various stressors in the brain change with age. However, little is known about the neural mechanisms underlying age-dependent changes in stress responses. It is known that serotonin, a stress-related transmitter, is closely related with the regulation of stress responses in the brain and that serotonergic function is modulated by various factors, including estrogen, in both sexes. ...
متن کاملSex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity.
BACKGROUND Women are twice as likely as men to suffer from stress-related affective disorders. Corticotropin-releasing factor (CRF) is an important link between stress and mood, in part through its signaling in the serotonergic dorsal raphe (DR). Development of CRF receptor-1 (CRFr1) antagonists has been a focus of numerous clinical trials but has not yet been proven efficacious. We hypothesize...
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Serotonin (5-HT) is implicated in the development of stress-related mood disorders in humans. Physical activity reduces the risk of developing stress-related mood disorders, such as depression and anxiety. In rats, 6 weeks of wheel running protects against stress-induced behaviors thought to resemble symptoms of human anxiety and depression. The mechanisms by which exercise confers protection a...
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The localisation of carletinin in the midbrains of 10 sexually mature chinchilla males was examined by carrying out the peroxidase-antiperoxidase immunocytochemical reaction using specific monoclonal antibody against calretinin. Intensive immunostaining for the protein was observed in the majority of fusiform, pyramidal, and stellate neurons of dorsal raphe nucleus. A similar calretinin distrib...
متن کاملChronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.
Alpha 1-adrenergic receptors (α1-ARs) control the activity of dorsal raphe nucleus (DRn) serotonin (5-HT) neurons and play crucial role in the regulation of arousal and stress homoeostasis. However, the precise role of these receptors in regulating glutamate synapses of rat DRn 5-HT neurons and whether chronic stress exposure alters such regulation remain unknown. In the present study, we exami...
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ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 2010
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2010.03.003